Bringing model systems closer to the clinic

Goal of the clonal redesign lab is to change a tumor’s environment so as to favor certain tumor subclones over others. We will redesign a tumor’s fitness landscape, rather than directly the clones themselves. Why then clonal redesign? Because by redesigning the environment, adaptation of clones to the new environment is implicit. Anticipating and preparing for this adaptation is at the core of our lab.


We combine computational biology, mathematical modeling and pharmacology to up our odds in the race against tumor evolution.


Our research program runs on two parallel tracks, the first complementing and supporting the second. The first track aims to improve consilience among clone perspectives: developing methods to quantify the clonal composition of a tumor from different perspectives, such as their genome, transcriptome, or appearance, and integrating those methods with each other. In short, the first track characterizes clones. The second track uses these clone characteristics to make treatment predictions.


Image by Colin Behrens from Pixabay

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